AnAnaS

About

Analytical Analyzer of  Symmetries is a software for detection and assessment of the quality of symmetry in a protein assembly. It can compute axes of symmetry for any type of point groups (Cyclic, Dihedral and Cubic).

Method

The process of symmetry detection is divided into several steps. At the beginning, only information about the coordinates of atoms and the sequence for each chain is available :

1. The chains are clustered into symmetric sets.
2. The correspondences are computed between different chains of symmetric sets.
3. The axes are computed to minimize the asymmetry of the assembly

This software can :

1. Detect the best axes of symmetry for any symmetry group in an assembly containing the right amount of chains.
2. Provide the symmetry-aware RMSD for these axes.
3. Detect the best axis of symmetry for cyclic assemblies with missing subunits.
4. Compute the axes of symmetry with user-provided correspondences.

Authors

Guillaume Pagès¹ & Sergei Grudinin¹,

¹Nano-D team, Inria/CNRS Grenoble, France

e-mail: Sergei.Grudinin @ inria.fr

Download

AnAnaS for MacOS (v. 1.1)

AnAnaS for Linux (v. 1.1)

AnAnaS for Windows (v. 0.6)

AnAnaS Manual and examples

AnAnaS GUI is available at https://www.samson-connect.net

References

• Analytical symmetry detection in protein assemblies. I. Cyclic symmetries. Guillaume Pagès, Elvira Kinzina, Sergei Grudinin. Journal of Structural Biology, Elsevier, 2018, 203 (2), pp.142-148. 〈10.1016/j.jsb.2018.04.004〉
• Analytical symmetry detection in protein assemblies. II. Dihedral and Cubic symmetries. Guillaume Pagès, Sergei Grudinin. Journal of Structural Biology, Elsevier, 2018, 203 (3), pp.185-194. 〈10.1016/j.jsb.2018.05.005〉

License

All rights reserved. The academic version is free. Source code is available on demand.