Séminaire Biocore : Eduardo Sontag (Rutgers)
Lundi 27 juin à 11h, Inria Sophia Antipolis, salle Euler Violet
Titre: Qualitative features of transient responses. A case study:
scale-invariance
Résumé: This talk will review the biological phenomenon, and formulate a
theoretical framework leading to a general theorem characterizing scale
invariant behavior by equivariant actions on sets of vector fields that
satisfy appropriate Lie-algebraic nondegeneracy conditions. The theorem
allows one to make experimentally testable predictions, and the
presentation will discuss the validation of these predictions using
genetically engineered bacteria and microfluidic devices, as well their
use as a “dynamical phenotype” for model invalidation. If there is time,
the talk will close with some very speculative remarks about the role of
the shape of transient responses in immune system self/other recognition
and in current cancer immunotherapy.
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