Irene Vignon-Clementel

Senior researcher (Directrice de recherche) at Inria
Inria Saclay Île-de-France Research Center

irene.vignon-clementel[at]inria.fr
Office 2101
Batiment Alan Turing
Campus de l’École Polytechnique
1 rue Honoré d’Estienne d’Orves
91120 Palaiseau, France

Publications

• 3 representative publications to download
• List of main publications
• Link to google scholar search

Scientific interests

• Mathematical Modeling and Numerical Methods
  • boundary conditions for physiological fluid dynamics (3D,1D)
  • multi-domain modeling & numerical methods for their coupling
  • model parametrisation from real data (multi-level approach, data assimilation)
  • combining biophysical modeling and machine-learning

• Applications
  • congenital heart disease (single ventricle, ToF) & acquired disease (aneurysms, coronary disease,…)
  • treatment planning & evaluation (liver surgery, pulmonary hypertension/CHD palliation)
  • airflow and particle deposition in health and disease
  • non-invasiving image (in particular dynamic contrast enhanced imaging)

PhD Students

PhD students (formal advising)

• Jérôme Kowalski (2022-), IP Paris (coadvisors: L Sala & D Drasdo)
• Raoul Sallé de Chou (2021-), U. Paris-Saclay (coadvisors: H Talbot & L Najman)
  Heart perfusion maps by machine learning
• Mahdi Rezaei Adariani (2021-), U. de Montréal, Canada (coadvisors: G Soulez, C Debbaut)
• Omar Ali (2020-2023), U. Paris-Saclay (coadvisors: E Vibert, MM Rohé)
  Artificial intelligence for the development of a digital decision support tool for the curative treatment of primary liver tumors
• Nicolas Golse (2021), PhD student in medicine (ED de Cancérologie 582, coadvisors: E Vibert and S Cotin), Anatomical, hemodynamic and physiological modeling of the liver for liver surgery. Now MCU (equiv. Assistant Professor) at U. Paris-Saclay, School of Medicine
• Noémie Boissier (2018), Sorbonne U. (coadvisor: D Drasdo) Blood and bile flow modeling in healthy and damaged liver micro-architecture. Now at EDF Store & Forecast.
• Nicolas Pozin (2017), Sorbonne U. (coadvisor: C Grandmont)
  Multiscale lung ventilation modeling in health and disease. Now at Primaa & Volunteer
• Chloé Audebert (2017), Sorbonne U. (coadvisor: JF Gerbeau)
  Multiscale modeling of liver: perfusion and function in hepatectomy. Prix de thèse AMIES 2018. Now MCF (equiv. Assistant Professor) at Sorbonne U., France.
• Gregory Arbia (2014), Sorbonne U. (coadvisor: JF Gerbeau) Multiscale modeling of blood flow applied to congenital heart disease. Now at CHOICE, France.

PhD students (unofficial advising)

• Clara Jaquet, (2018) PhD student at U. Paris-Est. Advisors: H Talbot & L Najman. Toward simulation of myocardial perfusion based on a single CTA scan. Now at Vironova, Sweden.
• Mohamed Bekheit (MD, 2018), PhD student at U. Paris Saclay, doctoral school of therapeutic innovation, France. Advisor: E Vibert. Multiscale study of liver volume evolution after major hepatectomy in a porcine model. Now Surgeon in UK.
• Florian Joly (2019), PhD student at U. Montreal, Canada. Advisors: C Kauffmann, G Soulez. Numerical Insights for AAA Growth Understanding and Predicting: Morphological and Hemodynamic Risk Assessment Features and Transient Coherent Structures Uncovering. Now data analyst at APHP, France.
• Stephanie Lindsey (2015), PhD student at Cornell University, USA. Advisor:  J Butcher.  Hemodynamic regulation of cardiac outflow morphogenesis. Now Assistant Professor at UCSD, USA.
• Mahdi Esmaily-Moghadam (2014), PhD student at UCSD, USA. Advisor: A. Marsden. Development of multiscale modeling methods for clinical decision making in single ventricle heart patients. Now Assistant Professor at Cornell University, USA.
• Jessica Oakes (2013), PhD student at UCSD, USA. Advisors: C Darquenne (School of Medicine) and A. Marsden (School of Engineering). Aerosol Deposition in Healthy and Emphysematous Rat Lungs: Insights From MRI Measurements and Computational Simulations. Now Assistant Professor at Northeastern U., USA.
• Weiguang Yang (2012), PhD student at UCSD, USA. Advisor: A. Marsden. Surgical design for the Fontan procedure using computational fluid dynamics and derivative-free optimization. Now research fellow at Stanford U, USA.
• Nick Jagiella (2012), PhD student at UPMC/U. of Leipzig. Advisor: D Drasdo. Parametrisation of lattice-based tumor models from data. Now at Advanced RealTime Tracking Gmbh, Germany.
• Rashmi Raghu (2011), PhD student at Stanford University, USA of C Taylor. Computational models of blood flow in deformable arteries including viscoelasticity. Now at Pivotal Inc.
• H.J. Kim (2009), PhD student at Stanford University, USA of C Taylor.  3D finite-element modeling of blood flow in the coronary arteries. Now Associate Prof. at KAIST, South Korea.

Editorial activity

• International Journal for Numerical Methods in Biomedical Engineering, Wiley (associate editor, since 2018)

Grants and Awards

• EDITH, CSA Horizon 2020 (2022-2024)
• ERC consolidator grant (2020-2025)
• iLite, RHU (2017-2021, INRIA PI Dirk Drasdo)
• iFLOW, ANR Tecsan (2013-2017)
• Transatlantic Leducq grant – a Trans-Atlantic Network of Excellence for Cardiovascular Research, (2010-2016):  Multi-scale Modeling of Single Ventricle Hearts for Clinical Decision Support

• Grant to organize the 4^th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease,  France-Stanford Center fund, (2013-2014)
• CARDIO – Equipe associée / Associated team grant from INRIA (with Stanford University & associated colleagues), (2008-2013)
• Grant, France-Stanford Center fund, (2007-2008)
• Award for the Student Presentation Competition in the Biotechnology Specialty area at the World Congress of Computational Mechanics by the USACM and the USACM Executive Committee (Aug. 2006)
• Dean’s Postdoctoral Fellowship, Stanford School of Medicine (awarded in 2006)
• Predoctoral Fellowship, American Heart Association (Top recipient of the Western States, USA ; 2004-2006)
• 2nd prize of the student competition research presentation, BCATS conference, Stanford, Nov 2005
• Cambridge European Trust bursary (1999-2000)
• Scholarship from the Ecole Centrale Paris for the international program TimePlus (1999-2000)

Education

• HDR (Habilitation à diriger des recherches), Ecole Doctorale de Sciences Mathématiques Paris Centre, Université Pierre et Marie Curie, Paris, France – 2016.
• PhD, Department of Mechanical Engineering, Stanford University, USA, thesis under the supervision of Prof. Charles A. Taylor in the Cardiovascular Biomedical Research Laboratory (download PhD_thesis) – 2006
• MS (Part III), Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK – thesis under the supervision of Prof. Timothy Pedley in the Biological Mechanics Group – 2000
• Diplome d’ingénieur, Ecole Centrale Paris, France – 2000