ERC MoDeLLiver

MoDeLLiver is a scientific project funded by the European Research Council under a Consolidator Grant (2020-2025) and coordinated by Irene Vignon-Clementel at Inria Saclay, France.

       

Project abstract

Surgical interventions are based on patient data, and although they require careful planning, they may be revised during surgery. To better predict surgery outcome, several aspects must be considered, including the local point of intervention, whole organ perfusion and function as well as their interaction with the entire circulation. To address this complexity, the EU-funded MoDeLLiver project aims to develop a haemodynamic model to guide surgical interventions in the lung and liver. Researchers will also employ an injected substance model to unravel the link between non-invasive medical imaging and organ perfusion and function: this will be very useful to parameterize the model prior to the patient’s intervention. The new modelling tool is expected to bring personalized surgical simulation a step closer to reality.

Example of applications considered in the project

Multiscale modelling of Potts shunt in the treatment of suprasystemic idiopathic pulmonary artery hypertension
(collab. with S. Pant and the interventional cardiologists A. Sizarov and Y. Boudjemline)

Pant S, et al., Multiscale modelling of Potts shunt as a potential palliative treatment for suprasystemic idiopathic pulmonary artery hypertension: a paediatric case study. Biomech Model Mechanobiol. 2022 Apr;21(2):471-511.

Evaluation of postoperative risk in liver surgery
(collab. with N. Golse and E. Vibert from the Hôspital Paul-Brousse, AP-HP, Paris, France)


Golse N, et al., Predicting the risk of post-hepatectomy portal hypertension using a digital twin: A clinical proof of concept. Journal of Hepatology 2021 Mar;74(3):661-669. 

Hired researchers

Research assistant:

  • Leo Weiqiang

Post-doctoral fellows:

PhD students:

  • Jérôme Kowalski (2022)

Visiting PhD students:

  • Mahdi Rezaei Adariani from CHUM, Canada (main advisor: G. Soulez)
  • Pascalle Wijtjnes from TU/e, Netherlands

Main collaborators:

  • PhD, MD, Nicolas Golse

Former collaborators:

Comments are closed.