Local partners (Bordeaux area):
- Bergonié Institute
- University hospitals Pellegrin, Haut-Lévèque and Saint-André
- Laboratoire de l’Angiogénèse et du Micro-environnement des Cancers (LAMC, Inserm U1029)
- University hospital of Bondy
- Institut des Technologies Avancées en sciences du Vivant (ITAV, CNRS, Toulouse)
- Lab. Vectorology and Anticancerous Therapies (IGR, Paris)
- Center for Research on Cancer of Marseille, (CRCM Inserm UMR1068, CNRS UMR7258, Marseille)
- Laboratoire Ampère (CNRS, Lyon)
- Humanitas Research Hospital (Milan, Italy)
- R. Natalini (CNR Rome, Italy)
- A. Silve (Karlsruhe Institute of Technology, Germany)
- European Associated Laboratory “Pulsed Electric Fields Applications in Biology and Medicine” (EBAM) on electroporation
International Inria associate teams
- Num4SEP, Numerics for electroporation with the Dept. of Mechanical Engineering, University of California at Santa Barbara (local PI: F. Gibou).
Electroporation-based therapies (EPTs) consist in applying high voltage short pulses to cells in order to create defects in the plasma membrane. They provide interesting alternatives to standard ablative techniques, for instance for deep seated badly located tumors. However their use is still limited due to a lack of knowledge of tissue electroporation. The goal of the associate team is to focus on the multiscale numerical modeling of spheroid electroporation, in order to provide new insights in electroporation at the mesoscopic scales (spheroids provide interesting tumor-like biological models). Benefiting from the expertise of F. Gibou’s team in HPC for multiphysics, and the expertise of the team MONC in tumor growth and cell electroporation modeling, the goal of the associate team Num4SEP is to obtain accurate and efficient numerical tools for the quantitative evaluation of the EPTs at the mesoscopic scale. The overall objective is to provide numerical tools to model spheroid electroporation.
- METAMATS, Modeling ExperimenTAl MetAsTasiS with the Roswell Park Cancer Institute, Buffalo, NY, USA (local PI: J. Ebos)
The aim of the METAMATS associate team is to bring together a cancer biology experimental laboratory led by John ML Ebos (Roswell Park Cancer Institute) and the inria MONC team composed of applied mathematicians. The Ebos laboratory is specialized in the study of anti-cancer therapeutics (in particular, novel biologically targeted therapeutics such as anti-angiogenics and immunotherapies) on the development of metastases and produces unique, hard-to-obtain data sets on this process’ dynamics. The MONC team is specialized in mathematical models in oncology, with a dedicated axis about modeling support and methodological development for analysis of data from preclinical studies. In particular, the work of S. Benzekry puts emphasis on proposing, studying and validating mathematical models of metastatic development under the action of various therapeutic modalities. Indeed, metastatic expansion remains the main challenge in the treatment of cancer and integrative studies combining experiments, mathematical models and clinical data have the potential to yield predictive computational tools of help to assist both the design of clinical trials and clinical oncologists in therapeutic decisions such as the control of the toxicity/efficacy balance or the optimal combination of treatment modalities.
Other international partners
- H. Fathallah (University of Alabama at Birmingham, USA)
- T. Suzuki (Osaka University, Japan)