In a recent publication in the journal PloS Computational Biology, as part of Etienne Baratchart’s PhD work, combined efforts between researchers of the MONC team and the LAMC (Inserm U1029) revealed non-trivial insights on the biology of metastatic colonization. Indeed, the standard theory of metastatic development by which secondary tumor foci would grow independently from each other and from the primary tumor (i.e., with no mass exchanges), formalized by an adequate mathematical construct, was shown to be inconsistent with MRI data and quantifications of total cell number, in a murine model of metastatic renal cell carcinoma.
See our page on theoretical cancer biology and Baratchart et al., Computational Modelling of Metastasis Development in Renal Cell Carcinoma, Plos Comp Biol, 2015.
