Emrys Reginato

 

Research projects

I am a PhD student in Microcosme team, where I started in October 2020. My PhD project revolves around the study of the role of inheritance and cell division in cell-to-cell variability in growing cell populations.

During the last decades, sources of cell-to-cell variability have been studied to explain heterogeneity in isogenic cell populations. Those sources are divided into two main categories: intrinsic noise and extrinsic noise. The former describes variability due to randomness within each cell, while the latter is often considered to account for more macro-level sources of variability. My work focuses on the contribution of cell division (a type of extrinsic noise) in the observed cell-to-cell variability and on the quantification of inheritance of individual cell traits along generations, even when lineage information cannot be recovered from available data.

I mainly use statistical approaches such as maximum likelihood estimations and mixed-effects modelling tailored to the project’s specific needs.

Courses

 

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