Objectives
The objective of the course is to learn about the mathematical modelling of metabolic and gene regulatory networks. The course concerns both theoretical foundations and concrete applications to diverse systems of biological regulation. Applications will rely on the practical use of computer tools for the modelling, analysis and simulation of metabolic and gene regulatory networks.
Course program
Part 1. Systems biology and kinetic modeling (courses)
September 15, 2021: Introduction to the course, slides, article
September 22, 2021: Kinetic modeling of biochemical reaction networks, slides, article
Part 2. Metabolic network modeling (courses and practical)
September 29, 2021: Metabolic control theory, slides, article
October 6, 2021: Flux balance analysis, slides, article
October 13 and 20, 2021: Practical on the modeling of metabolic networks using COBRA, handout, corrected hand-out, code, models
Part 3. Gene regulatory network modeling (courses and practical)
November 3, 2021: Quantitative modeling of gene regulatory networks, slides, article
November 10, 2021: Qualitative modeling of gene regulatory networks, slides, article
November 24, 2020: Stochastic modeling of gene regulatory networks, slides, article
December 1 and December 8, 2020: Practical on the modeling of bacterial regulatory networks using MATLAB, handout, models
Evaluation
December 15, 2021: Feedback on mini-projects, list of mini-projects, presentation
Contact
Hidde de Jong (Hidde.de-Jong@inria.fr)
