David Drummond – HeKA team

David Drummond
PHU,
AP-HP – UP

email: david dot drummond at aphp.fr
postal address: Service de pneumologie et allergologie pédiatriques – Hôpital Necker-Enfants Malades – 149 rue de Sèvres 75015 Paris
web page: ResearchGate page
bio: David Drummond is assistant professor in the department of pediatric pulmonology of the university hospital Necker-Enfants Malades and at the Université de Paris. His research focuses on new technologies in the management of childhood asthma, particularly how continuous home-based monitoring of these children can lead to personalised, timely delivery of care.

Research projects

1. NOÛS – The vision
The ambition of the Noûs project is to position France on the international market of digital medicine, by developing ecosystems combining continuous data collection and autonomous algorithmic decision-making systems.
The advent of the era of continuous data collection, at the origin of big data, and of its large-scale processing, thanks to machine learning techniques, now makes possible a 4P medicine, participative, predictive, preventive, and personalized, as prophesied by the American researcher Leroy Hood in 20111.
Noûs is first and foremost We, patients, patients’ families, health professionals, industrialists, investors, who share this ambition for France and for Europe. Noûs is a hat on the u that makes a roof to a house, the mark of a medicine made at home, from our homes. Noûs, it is finally the Greek notion of intellect defended by Anaxagoras, which unites intelligence and motor efficiency, and which, starting from an infinitely small central point, then spreads in a sphere of action whose radius increases.
We propose a first application of the Noûs project in childhood asthma.

2. NOÛS – The application in pediatric asthma
Asthma is the leading chronic disease in children worldwide, affecting 10-20% of children in developed countries, or 1.5 million children in France2. 2 Asthma attacks are one of the leading causes of emergency room visits and hospitalizations. 3 With current management, two-thirds of children continue to have symptoms on a weekly basis, and one in eight visits the emergency department each year. 4 The barriers to improving the management of these children can be summarized as follows:
(i) Data collection: the data collected by the doctor is based essentially on the questioning of the parents. However, it has been shown that these statements are erroneous5 . Moreover, these data are collected a posteriori during consultations and do not allow the detection of asthma destabilisation and the anticipation of attacks. On the other hand, Noûs offers, via connected objects (mobile application, connected inhalers, weather-pollen-pollution data), a continuous collection of asthma control and opens the way to a predictive, preventive and personalized medicine.
(ii) The algorithm: the problem with current recommendations is twofold: they are based on a one-size-fits-all approach, and are very little followed by physicians6,7. Noûs’ ambition is to propose automated management algorithms for asthma attacks on the one hand, and for background treatment on the other, based on machine learning, in this case reinforcement learning from data collected on the entire cohort of children monitored.
(iii) The problem of treatment: once inhaled treatments have been prescribed, these treatments must be taken with a compliance rate of over 75% to be effective, but also with an appropriate inhalation technique. However, to date, no tool is available to accompany children and their families at home in taking inhaled treatments. Noûs still offers solutions here (connected inhalers to monitor compliance, companion robot to accompany children to take their treatments with a good inhalation technique).
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3. NOÛS – Clinical Research Projects
3.1 Acceptability studies of digital medicine in paediatric asthma
– e-ASM study. Electronic self-management system for children’s asthma: the parents’ point of view. Acceptability study of digital medicine in pediatric asthma with 321 parents of asthmatic children recruited between September 2019 and February 2020 in 4 centers in France. 54% of parents said they were ready to use digital medicine including automated decision algorithms. Results published in April 2021 in JACI in Practice (Rank A, IF 7.57)8. Funding: no.
– CHAIA study. Artificial intelligence in the daily management of asthma, the child’s point of view. Following the reviewers’ remarks, launch of a similar study in children and adolescents, multicentric intra-APHP (Necker, Trousseau), this time integrating a qualitative part allowing to collect the ideas of asthmatic children and adolescents. Agreement 2021-03-04 of the CERAPHP.centre on 2/6/2021. Inclusions from July 1, 2021 to June 1, 2022, target 104 asthmatic children between 8 and 12 years old. Funding: no.

3.2 Digital transformation of data for use by algorithms
– COPA study. Towards an algorithmic approach to asthma management: collaborative definition of algorithm objectives with families. Qualitative study via interview, then quantitative second part on questionnaire, aiming at identifying the priority objective(s) that children, parents, and their physicians wish to reach when they take/supervise the taking/prescribing of a background treatment, so that these objectives can be entered in the future decision algorithms. Multicenter intra-APHP study (Necker, Trousseau, Robert Debré, Ambroise Paré, Louis Mourier). CPP submission in May 2021, answers provided in July 2021, waiting for final authorization to start inclusion. Inclusion target: 200 asthmatic children aged 8 to 17, their parents, and their physicians, between September 1, 2021 and June 1, 2022. Funding: no.
– ASBOT study. Development and validation of a questionnaire measuring the “burden of treatment” in pediatric asthma. This questionnaire with a child and a parent side will allow to obtain a numerical measure of the “burden of treatment” which will represent a new data that can be entered in the algorithms. National multicentre study (Necker, Ambroise Paré, Trousseau, Brest, Lyon, Limoges, Nice). Inclusion target: 200 asthmatic children aged 8 to 12 years and their parents (development of a child and parent version of the questionnaire). CPP submission July 2021. Inclusions planned between 1 November 2021 and 1 June 2022. Funding: no.

3.3 Preparing the development of the algorithms
– PACAP study. Participatory Childhood Asthma Action Plan. Objective: to provide asthmatic children with a connected inhaler linked to their ventolin in order to observe in real time the use of their emergency asthma treatment, and to develop from this field data a new action plan in case of asthma attack. The data collected will also be used to develop an algorithm for managing asthma attacks. Partnership Necker-APHP + INSERM/INRIA team HeKA (Health data- and model- driven Knowledge Acquisition) + KapCode company (connected inhalers). National multicenter study (Necker, Ambroise Paré, Trousseau, Brest, Lille, Lyon, Limoges). CPP agreement in April 2021, CNIL agreement in June 2021, signature of AP-HP/University of Paris contracts in progress. Inclusions planned between November 1, 2021 and June 1, 2022. Inclusion target: 150 asthmatic children aged 3 to 11 years and their parents. Funding: University of Paris (IDEX) €45,500; Fondation Paris Descartes €35,500.

3.4 Optimization of compliance monitoring and inhalation technique.
– Asthma JoeCare study. Randomized controlled trial evaluating the efficacy and tolerance of educational support for patients in taking their treatments via the companion robot Joe. Multicentric trial at the national level (15 recruiting centers). Promoted by the Ludocare company.
Principal investigator: David Drummond. PPC obtained in April 2021. Start of inclusion evaluated on October 1, 2021. Inclusion target: 210 asthmatic children aged 4 to 11 years over 6 months. Primary endpoint: number of severe asthma attacks. Intervention: “Joe” robot that rewards the child when he takes his treatment and goes through the different steps with him to respect a good inhalation technique. Foundation: Ludocare.

Publications
Publications HAL de david, drummond

2023

Journal articles

ref_biblio: David Drummond, Apolline Gonsard. Télésurveillance dans l’asthme pédiatrique : vers des systèmes cyber-physiques. Perfectionnement en Pédiatrie, 2023, 6 (4), pp.244-249. ⟨10.1016/j.perped.2023.10.009⟩. ⟨hal-04339220⟩
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ref_biblio: Anne Welfringer-Morin, Pauline Bataille, David Drummond, Nathalia Bellon, Saskia Ingen-Housz-Oro, et al.. Comparison of idiopathic and drug-induced epidermal necrolysis in children. British Journal of Dermatology, 2023, 189 (5), pp.631-633. ⟨10.1093/bjd/ljad226⟩. ⟨hal-04339226⟩
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ref_biblio: Job F.M. van Boven, David Drummond, Amy H.Y. Chan, Mark Hew, Chi Yan Hui, et al.. ERS “CONNECT” Clinical Research Collaboration – moving multiple digital innovations towards connected respiratory care: addressing the over-arching challenges of whole systems implementation. European Respiratory Journal, 2023, 62 (5), pp.2301680. ⟨10.1183/13993003.01680-2023⟩. ⟨hal-04339221⟩
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ref_biblio: Sophie Schmartz, Anne Welfringer-Morin, Muriel Le Bourgeois, Christophe Delacourt, Laureline Berteloot, et al.. Respiratory complications in pediatric epidermal necrolysis: A retrospective study of 22 cases. Journal of The American Academy of Dermatology, 2023, 89 (4), pp.857-859. ⟨10.1016/j.jaad.2023.05.092⟩. ⟨hal-04339228⟩
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ref_biblio: Sophie Schmartz, Anne Welfringer-Morin, Muriel Le Bourgeois, Christophe Delacourt, Laureline Berteloot, et al.. Respiratory complications in pediatric epidermal necrolysis: A retrospective study of 22 cases. Journal of The American Academy of Dermatology, 2023, 89 (4), pp.857-859. ⟨10.1016/j.jaad.2023.05.092⟩. ⟨hal-04339474⟩
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ref_biblio: Sophie Schmartz, Anne Welfringer-Morin, Muriel Le Bourgeois, Christophe Delacourt, Laureline Berteloot, et al.. Respiratory complications in pediatric epidermal necrolysis: A retrospective study of 22 cases. Journal of The American Academy of Dermatology, 2023, 89 (4), pp.857-859. ⟨10.1016/j.jaad.2023.05.092⟩. ⟨hal-04360102⟩
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ref_biblio: David Drummond, Jolt Roukema, Mariëlle Pijnenburg. Home monitoring in asthma: towards digital twins. Current Opinion in Pulmonary Medicine, 2023, 29 (4), pp.270-276. ⟨10.1097/MCP.0000000000000963⟩. ⟨hal-04339229⟩
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ref_biblio: David Drummond, Pauline Whelan, Matthew Sperrin. Association between nebuliser therapies adherence and visit-to-visit variability of FEV1 in patients with cystic fibrosis. Journal of Cystic Fibrosis, 2023, 22 (4), pp.702-705. ⟨10.1016/j.jcf.2023.03.006⟩. ⟨hal-04339233⟩
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ref_biblio: Apolline Gonsard, Rola Aboutaam, Blandine Prévost, Charlotte Roy, Alice Hadchouel, et al.. Children’s views on artificial intelligence and digital twins for the daily management of their asthma: a mixed-method study. European Journal of Pediatrics, 2023, 182 (2), pp.877-888. ⟨10.1007/s00431-022-04754-8⟩. ⟨hal-03993835⟩
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Books

ref_biblio: Hilary Pinnock, Vitalii Poberezhets, David Drummond. Digital Respiratory Healthcare. European Respiratory Society, 2023, ⟨10.1183/2312508X.erm10223⟩. ⟨hal-04339219⟩
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2022

Journal articles

ref_biblio: Jennifer Truchot, Daphné Michelet, Anne Laure Philippon, David Drummond, Yonathan Freund, et al.. Effect of a specific training intervention with task interruptions on the quality of simulated advance life support: A randomized multi centered controlled simulation study. Australasian Emergency Care, 2022, ⟨10.1016/j.auec.2022.10.001⟩. ⟨hal-03986126⟩
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ref_biblio: David Drummond, Alice Hadchouel, Arnaud Petit, Naziha Khen-Dunlop, Cécile Lozach, et al.. Strategies for recognizing pneumonia look-alikes. European Journal of Pediatrics, 2022, 181 (10), pp.3565-3575. ⟨10.1007/s00431-022-04575-9⟩. ⟨hal-03866696⟩
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ref_biblio: Thao Nguyen-Khoa, Aurélie Hatton, David Drummond, Laura Aoust, Joël Schlatter, et al.. Reclassifying inconclusive diagnosis for cystic fibrosis with new generation sweat test. European Respiratory Journal, 2022, 60 (2), pp.2200209. ⟨10.1183/13993003.00209-2022⟩. ⟨hal-03866713⟩
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ref_biblio: Fabienne Charbit-Henrion, Roman Goguyer-Deschaumes, Keren Borensztajn, Marc Mirande, Jérémy Berthelet, et al.. Systemic inflammatory syndrome in children with FARSA deficiency. Clinical Genetics, 2022, 101 (5-6), pp.552-558. ⟨10.1111/cge.14120⟩. ⟨inserm-03790743⟩
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ref_biblio: Harriet Corvol, Sandra de Miranda, Clémence Dehillotte, Lydie Lemonnier, Raphael Chiron, et al.. Cumulative Incidence and Risk Factors for Severe Coronavirus Disease 2019 in French People With Cystic Fibrosis. Clinical Infectious Diseases, 2022, ⟨10.1093/cid/ciac333⟩. ⟨hal-03827698⟩
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ref_biblio: David Drummond, Jérémy Dana, Laureline Berteloot, Elena Schneider-Futschik, Frédérique Chedevergne, et al.. Lumacaftor-ivacaftor effects on cystic fibrosis-related liver involvement in adolescents with homozygous F508 del-CFTR. Journal of Cystic Fibrosis, 2022, 21 (2), pp.212-219. ⟨10.1016/j.jcf.2021.07.018⟩. ⟨hal-03866719⟩
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ref_biblio: David Drummond. Outils connectés pour la télésurveillance des patients asthmatiques : gadgets ou révolution?. Revue des Maladies Respiratoires, 2022, 39 (3), pp.241-257. ⟨10.1016/j.rmr.2022.01.018⟩. ⟨hal-03866739⟩
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ref_biblio: David Drummond, Adrien Coulet. Technical, Ethical, Legal, and Societal Challenges With Digital Twin Systems for the Management of Chronic Diseases in Children and Young People. Journal of Medical Internet Research, 2022, 24 (10), pp.e39698. ⟨10.2196/39698⟩. ⟨hal-03835708⟩
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2021

Journal articles

ref_biblio: David Drummond, Caroline Thumerelle, Antoine Roux, Clémence Mordacq, Pierre Frange, et al.. Severe COVID‐19 evolving towards organizing pneumonia in a pediatric lung transplant recipient. Pediatric Pulmonology, 2021, 57 (2), pp.583-585. ⟨10.1002/ppul.25744⟩. ⟨hal-04482322⟩
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ref_biblio: Alice Hadchouel, David Drummond, Clément Pontoizeau, Laura Aoust, Maria-Margarita Hurtado Nedelec, et al.. Methionine supplementation for multi-organ dysfunction in MetRS-related pulmonary alveolar proteinosis. European Respiratory Journal, 2021, pp.2101554. ⟨10.1183/13993003.01554-2021⟩. ⟨hal-03447784⟩
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ref_biblio: Stéphane Gargula, Romain Luscan, David Drummond, Françoise Denoyelle, Vincent Couloigner, et al.. French translation and validation of the Sinus and Nasal Quality of Life Survey (SN-5) in children. International Journal of Pediatric Otorhinolaryngology, 2021, 145, pp.110706. ⟨10.1016/j.ijporl.2021.110706⟩. ⟨hal-03866708⟩
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ref_biblio: David Drummond. Between competence and warmth: the remaining place of the physician in the era of artificial intelligence. npj Digital Medicine, 2021, 4 (1), pp.85. ⟨10.1038/s41746-021-00457-w⟩. ⟨hal-03229495⟩
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ref_biblio: Guillaume Lezmi, Stéphanie Lejeune, Isabelle Pin, Sylvain Blanchon, Naïm Bouazza, et al.. Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort. Journal of Allergy and Clinical Immunology: In Practice, 2021, 9 (5), pp.1969-1979. ⟨10.1016/j.jaip.2020.12.027⟩. ⟨hal-03238438⟩
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ref_biblio: Adrien Coulet, Stéphanie Allassonniere, François Angoulvant, Anita Burgun, Xiaoyi Chen, et al.. L’équipe-projet HeKA. Bulletin de l’Association Française pour l’Intelligence Artificielle, 2021, 112, pp.29-32. ⟨hal-03485904⟩
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ref_biblio: Cindy Abdoul, Pierrick Cros, Laurianne Coutier, Alice Hadchouel, Antoine Neuraz, et al.. Parents’ views on artificial intelligence for the daily management of childhood asthma: a survey. Journal of Allergy and Clinical Immunology: In Practice, 2021, 9 (4), pp.1728-1730.e3. ⟨10.1016/j.jaip.2020.11.048⟩. ⟨hal-03476824⟩
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ref_biblio: Naïm Ouldali, Julie Toubiana, Denise Antona, Etienne Javouhey, Fouad Madhi, et al.. Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children. JAMA Cardiology, 2021, 325 (9), pp.855. ⟨10.1001/jama.2021.0694⟩. ⟨hal-03807238⟩
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ref_biblio: Elodie Billion, Alice Hadchouel, Nicolas Garcelon, Christophe Delacourt, David Drummond. Intravenous pulses of methylprednisolone for infants with severe bronchopulmonary dysplasia and respiratory support after 3 months of age. Pediatric Pulmonology, 2021, 56 (1), pp.74-82. ⟨10.1002/ppul.25109⟩. ⟨hal-03402539⟩
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2020

Journal articles

ref_biblio: Alice Hadchouel, David Drummond, Rola Abou Taam, Muriel Lebourgeois, Christophe Delacourt, et al.. Alveolar proteinosis of genetic origins. European Respiratory Review, 2020, 29 (158), pp.190187. ⟨10.1183/16000617.0187-2019⟩. ⟨hal-03866698⟩
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ref_biblio: Tristan Fonteneau, Elodie Billion, Cindy Abdoul, Sebastien Le, Alice Hadchouel, et al.. Simulation Game Versus Multiple Choice Questionnaire to Assess the Clinical Competence of Medical Students: Prospective Sequential Trial. Journal of Medical Internet Research, 2020, 22 (12), pp.e23254. ⟨10.2196/23254⟩. ⟨hal-03866721⟩
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2019

Journal articles

ref_biblio: David Drummond, Alice Hadchouel, Muriel Le Bourgeois, Jean Christophe Rozé, Stéphane Marret, et al.. Decreased pulmonary capillary volume in adolescents born very preterm. Acta Paediatrica, 2019, 109 (3), pp.621-622. ⟨10.1111/apa.15023⟩. ⟨hal-03866702⟩
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ref_biblio: Daphné Michelet, Jennifer Truchot, Marie-Aude Piot, David Drummond, Pierre-François Ceccaldi, et al.. Perioperative laryngospasm management in paediatrics: a high-fidelity simulation study. BMJ Simulation and Technology Enhanced Learning, 2019, 5 (3), pp.161-166. ⟨10.1136/bmjstel-2018-000364⟩. ⟨hal-03866711⟩
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ref_biblio: David Drummond, Alice Hadchouel, Heloise Torchin, Jean-Christophe Rozé, Catherine Arnaud, et al.. Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm.. PLoS ONE, 2019, 14 (9), pp.e0222286. ⟨10.1371/journal.pone.0222286⟩. ⟨hal-02620115⟩
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2018

Journal articles

ref_biblio: Agnès Frémont, Rola Abou Taam, Stéphanie Wanin, Marie-Noëlle Lebras, Vincent Ollier, et al.. Cartoons to improve young children’s cooperation with inhaled corticosteroids: A preliminary study. Pediatric Pulmonology, 2018, 53 (9), pp.1193-1199. ⟨10.1002/ppul.24070⟩. ⟨hal-03866718⟩
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ref_biblio: David Drummond, Cécile Arnaud, Romain Guedj, Alexandre Duguet, Nathalie de Suremain, et al.. Fixed versus variable practice for teaching medical students the management of pediatric asthma exacerbations using simulation. European Journal of Pediatrics, 2018, 177 (2), pp.211-219. ⟨10.1007/s00431-017-3054-1⟩. ⟨hal-03866724⟩
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Theses

ref_biblio: David Drummond. Conception et développement d’un simulation game pour les parents d’enfants de moins de 6 ans avec asthme : une approche evidence-based. Education. Université Sorbonne Paris Cité, 2018. Français. ⟨NNT : 2018USPCB006⟩. ⟨tel-02464953⟩
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2017

Journal articles

ref_biblio: David Drummond, Alice Hadchouel, Antoine Tesnière. Serious games for health: three steps forwards. Advances in Simulation, 2017, 2 (1), pp.3. ⟨10.1186/s41077-017-0036-3⟩. ⟨hal-03866706⟩
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ref_biblio: David Drummond, Eleonora Fabbro, Antoine Tesnière, Alice Hadchouel. Toward virtual simulation for parents of children with asthma. The Journal of Allergy and Clinical Immunology: In Practice, 2017, 5 (6), pp.1779-1781.e6. ⟨10.1016/j.jaip.2017.04.017⟩. ⟨hal-03866707⟩
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ref_biblio: David Drummond, Delphine Monnier, Antoine Tesnière, Alice Hadchouel. A systematic review of serious games in asthma education. Pediatric Allergy and Immunology, 2017, 28 (3), pp.257-265. ⟨10.1111/pai.12690⟩. ⟨hal-03866704⟩
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ref_biblio: David Drummond, Mélissa Baravalle-Einaudi, Guillaume Lezmi, Shamila Vibhushan, Marie-Laure Franco-Montoya, et al.. Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice. Environmental Health Perspectives, 2017, 125 (3), pp.392-399. ⟨10.1289/EHP54⟩. ⟨hal-03866728⟩
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ref_biblio: David Drummond, Cécile Arnaud, Romain Guedj, Alexandre Duguet, Nathalie de Suremain, et al.. Google Glass for Residents Dealing With Pediatric Cardiopulmonary Arrest. Pediatric Critical Care Medicine, 2017, 18 (2), pp.120 – 127. ⟨10.1097/PCC.0000000000000977⟩. ⟨hal-01675554⟩
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ref_biblio: David Drummond, Paul Delval, Sonia Abdenouri, Jennifer Truchot, Pierre-François Ceccaldi, et al.. Serious game versus online course for pretraining medical students before a simulation-based mastery learning course on cardiopulmonary resuscitation. European Journal of Anaesthesiology, 2017, 34 (12), pp.836-844. ⟨10.1097/EJA.0000000000000675⟩. ⟨hal-03866729⟩
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2014

Journal articles

ref_biblio: David Drummond, Julie Starck. Fond of My Patient. Hastings Center Report, 2014, 44 (4), pp.7-8. ⟨10.1002/hast.322⟩. ⟨hal-03866700⟩
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Master thesis

ref_biblio: David Drummond. Évaluation d’un programme d’enseignement innovant associant film pédagogique et ateliers de simulation pour la formation à l’arrêt cardiaque de l’enfant des étudiants hospitaliers. Médecine humaine et pathologie. 2014. ⟨dumas-01190204⟩
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