BIGS is a team common to Inria, CNRS and Université de Lorraine, via the Institut Élie Cartan, UMR 7502 CNRS-UL laboratory in mathematics, of which Inria is a strong partner. One member of BIGS, T. Bastogne, comes from the Centre de Recherche en Automatique de Nancy (CRAN), laboratory in the domain of Automatics with which BIGS has strong relations in the domain “Health-Biology-Signal”. Our research is mainly focused on stochastic modeling and statistics for a methodological purpose but also aiming at a better understanding of biological systems. BIGS is composed of applied mathematicians whose research interests mainly concern probability and statistics. More precisely, our attention is directed on (1) stochastic modeling, (2) estimation and control for stochastic processes, (3) algorithms and estimation for graph data and (4) regression and machine learning. The main objective of BIGS is to exploit these skills in applied mathematics to provide a better understanding of some issues arising in life sciences, with a special focus on (1) tumor growth, (2) photodynamic therapy, (3) genomic data and micro-organisms population study, (4) epidemiology and e-health.