We propose a new method called Totoro, for “Transient respOnse to meTabOlic pertuRbation inferred at the whole netwOrk level”, which is a constraint-based approach that integrates internal metabolite concentrations that were measured before and after a perturbation into genome-scale metabolic reconstructions. It predicts reactions that were active during the transient state that occurred after the perturbation. The method is solely based on metabolomic data.
Contacts: Irene Ziska and Marie-France Sagot.
