Year 2024

Reaseach visits and activities

• Arthur Hughes visited Layla Parast’s group at UT Austin (TX, USA) during 1 month in May
• 1 week RISE (Rank-based Identification of Surrogates in Small Ebola Studies) workshop with , Denis Agniel, Boris Hejblum, Benjamin Hivert, Arthur Hughes & Layla Parast at UT Austin (TX, USA) in June ; funded in part through the Dr. Cécile DeWitt-Morette France-UT Endowed Excellence Fund
• Strategic meeting between Layla Parast & Boris Hejblum in June at the ISNPS 2024 in Braga (Portugal)

Scientific communications

• Oral presentations:
  • A Hughes gave a contributed talk at the 45th Annual Conference of the International Society for Clinical Biostatistics 2024 in Thessaloniki (Greece) on “A variance-component score test for the comparison of gene-set transcriptomic profiles of vaccine”
  • S Fallet gave a contributed talk at the 2024 Statistical Methods for Post Genomic Data conference in Paris (France) on “Conditional cumulative distribution function testing for gene set analysis of single-cell RNA-seq data”
  • B Hejblum gave an invited talk at the International Symposium on Nonparametric Statistics 2024 in Braga (Portugal) on “Conditional independence testing by comparing empirical conditional cumulative distribution functions”

Scientific progress:

• Completed:
  • “Post-clustering difference testing: valid inference and practical considerations” article publication in  Computational Statistics & Data Analysis (DOI: 10.1016/j.csda.2023.107916)
  • “Running in circles: Is practical application feasible for data fission and data thinning in post-clustering differential analysis?“ preprint on arXiv (arxiv:2405.13591)
• Ongoing:
  • development of a new framework for surrogacy screening of transcriptomics data in vaccine trials

Year 2023

Reaseach visits and activities

• 1 week workshop at RAND offices in Boston (MA, USA), that led to
  • the submission of an NIH R21 project entitled DESIRE (Development of Early Surrogate for Immune Response to Ebola vaccination), as well as
  • an award from Dr. Cécile DeWitt-Morette France-UT Endowed Excellence Fund for our RISE (Rank-Based Identification of Surrogates in Small Ebola Studies) proposal.
• Rebecca Knowlton visited the SISTM team in Bordeaux for 2 weeks in November

Scientific communications

• Oral presentations:
  • B Hivert gave a contributed talk at the 2023 Statistical Methods for Post Genomic Data conference in Ghent on “Post-clustering Differential Testing:  valid inference and practical considerations”
  • B Hivert gave a contributed talk at the EuroBioc2023 conference in Ghent on “Data fission for post-clustering differential analysis using dearseq”
  • B Hivert gave a contributed talk at the 2023 Journées de la Statistiques de la SFDS in Bruxelles on “Apports et Challenges de la Fission de Données pour les problèmes d’inférences post-clustering“
• Posters:

• • B Hivert had a written communication at the 44th Annual Conference of the International Society for Clinical Biostatistics in Milano on “Contributions and challenges of data fission for post-clustering differential analysis”

Scientific progress:

• Completed:
  • “Post-clustering difference testing: valid inference and practical considerations” preprint on arXiv (arxiv:2210.13172)
  • “Doubly-robust evaluation of high-dimensional surrogate markers” article published in Biostatistics (DOI: 10.1093/biostatistics/kxac020)
• Ongoing:
  • characterization of the properties of data-fission and data-thining for post-clustering inference, especially when applied to high-dimensionnal correlated data
  • development of a new framework for optimal surrogacy analysis in vaccine development

Year 2022

Reaseach visits and activities

• D Agniel, B Hejblum and L Parast all met, presented and actively participated in the BIRS-CMO 22w5184 workshop on “Statistical challenges in the identification, validation & use of surrogate markers”

Communications

• Oral presentations:
  • B Hejblum gave a contributed talk at the 2022 International Biometric Conference in Riga on “Distribution-free complex hypothesis testing for single-cell RNA-seq differential expression analysis”
  • B Hivert gave a contributed talk at the 2022 International Biometric Conference in Riga on “Post-clustering differential expression analysis: valid inference and practical considerations”
  • B Hivert gave a contributed talk at the 2021 Journées nationales « Statistiques & Santé » online  on “Inférence post-clustering pour l’identification des variables responsables de la séparation de paires de clusters”
  • B Hivert gave a contributed talk at the Journées de la statistique de la SFDS in Lyon on “Post-clustering differential expression analysis: valid inference and practical considerations”

Scientific progress

• Completed:
  • implementation and publication of a new method for doubly-robust evaluation of high-dimensional surrogate markers published in Biostatistics and available in the crossurr R package available on CRAN
  • implementation of the in the VALIDICLUST R package available on CRAN
• Ongoing:
  • development of a new framework for post-clustering differential testing for high-dimensionnal correlated data leveraging data-fission
  • development of a new framework for optimal surrogacy analysis in vaccine development (R21 application to NIH)